Representative Publications from Core Faculty Members

  • Pawar A, Peng YJ, Jacono FJ, Prabhakar NR. Comparative analysis of neonatal and adult rat carotid body responses to chronic intermittent hypoxia. J Appl Physiol. 2008 Jan 10; [Epub ahead of print].
  • Kuri BA, Khan SA, Chan SA, Prabhakar NR, Smith CB. Increased secretory capacity of mouse adrenal chromaffin cells by chronic intermittent hypoxia: involvement of protein kinase C. J Physiology. 584:313-9. 2007.
  • Prabhakar NR, Kumar GK, Nanduri J, Semenza GL. ROS signaling in systemic and cellular responses to chronic intermittent hypoxia. Antioxid Redox Signal. 9:1397-403. 2007.
  • Prabhakar NR. Novel role for reactive oxygen species as amplifiers of intermittent hypoxia. J Neurophysiol. 97:1877-78. 2007.
  • Prabhakar NR, Dick TE, Nanduri J, Kumar GK. Systemic, cellular and molecular analysis of chemoreflex-mediated sympathoexcitation by chronic intermittent hypoxia. Exp Physiol. 92:39-44. 2007.
  • Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, and Semenza GL. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell. 11:407-20, 2007.
  • Nanduri J and N.R. Prabhakar. Cellular mechanisms associated with intermittent hypoxia. Essays Biochem. 43:91-104. 2007.
  • Peng YJ, Yuan G, Ramakrishnan D, Sharma SD, Bosch-Marce M, Kumar GK, Semenza GL, Prabhakar NR. Heterozygous HIF-1alpha deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. J Physiol. 577:705-16. 2006.
  • Kumar GK, Rai V, Sharma SD, Ramakrishnan DP, Peng YJ, Souvannakitti D, Prabhakar NR. Chronic intermittent hypoxia induces hypoxia-evoked catecholamine efflux in adult rat adrenal medulla via oxidative stress. J Physiol. 575:229-39. 2006.
  • Prabhakar NR, Peng YJ, Yuan G, Kumar GK. Reactive oxygen species facilitate oxygen sensing. Novartis Found Symp. 2006;272:95-9; discussion 100-5, 131-40.
  • Prabhakar NR. O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters? Exp Physiol. 91:17-23. 2006.
  • Kline DD, Buniel MC, Glazebrook P, Peng YJ, Ramirez-Navarro A, Prabhakar NR, Kunze DL. Kv1.1 deletion augments the afferent hypoxic chemosensory pathway and respiration. J Neurosci. 25:3389-99, 2005.
  • Yuan G, Nanduri J, Bhasker CR, Semenza GL, Prabhakar NR. Ca2+/calmodulin kinase-dependent activation of hypoxia inducible factor 1 transcriptional activity in cells subjected to intermittent hypoxia. J Biol Chem. 280:4321-8. 2005.
  • Prabhakar NR, Kumar GK. Oxidative stress in the systemic and cellular responses to intermittent hypoxia. Biol Chem. 385:217-21. 2004.
  • Peng YJ, Overholt JL, Kline D, Kumar GK, Prabhakar NR. Induction of sensory long-term facilitation in the carotid body by intermittent hypoxia: implications for recurrent apneas. Proc Natl Acad Sci U S A. 100:10073-8. 2003.
  • Kline DD, Peng YJ, Manalo DJ, Semenza GL, Prabhakar NR. Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1a. Proc Natl Acad Sci U S A. 99:821-6. 2002.
  • Prabhakar NR. Sleep apneas: an oxidative stress? Am J Respir Crit Care Med. 165:859-60. 2002.