Adequate availability of oxygen (O2) is essential for the survival because of its critical role in generating energy via ATP. Hypoxia, i.e., decreased availability of O2, occurs under a variety of physiological and pathophysiological situations. The ill effects of hypoxia can be alleviated to some extent by supplemental O2 therapy, a widely used clinical practice, which can also result in unwanted physiological consequences by generating O2 metabolites known as reactive oxygen species (ROS).
Physiological consequences of hypoxia and hyperoxia are well appreciated for several decades by respiratory physiologists and pulmonary physicians. In recent years, the field of O2 biology, which encompasses molecular, cellular and systemic consequences of low and high O2 as well as ROS, attracted the attention of researchers from other disciplines of medicine, physiology as well as cell and molecular biology. Revolutionary advances in various areas of O2 biology provide new opportunities for novel therapeutic interventions for a variety of diseases.
COMPARATIVE ANALYSIS OF NEONATAL AND ADULT RAT CAROTID BODY RESPONSES TO CHRONIC INTERMITTENT HYPOXIA. Previous studies suggest that carotid body responses to long-term changes in environmental oxygen differ between neonates and adults. More . . .